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相关概念视频

Nuclear Power02:36

Nuclear Power

Controlled nuclear fission reactions are used to generate electricity. Any nuclear reactor that produces power via the fission of uranium or plutonium by bombardment with neutrons has six components: nuclear fuel consisting of fissionable material, a nuclear moderator, a neutron source, control rods, reactor coolant, and a shield and containment system.
Nuclear Fuels
Nuclear fuel consists of a fissile isotope, such as uranium-235, which must be present in sufficient quantity to provide a...
Nuclear Fusion02:45

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Nuclear Transmutation03:20

Nuclear Transmutation

Nuclear transmutation is the conversion of one nuclide into another. It can occur by the radioactive decay of a nucleus, or the reaction of a nucleus with another particle. The first manmade nucleus was produced in Ernest Rutherford’s laboratory in 1919 by a transmutation reaction, the bombardment of one type of nuclei with other nuclei or with neutrons. Rutherford bombarded nitrogen-14 atoms with high-speed α particles from a natural radioactive isotope of radium and observed protons being...
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Somatic to iPS Cell Reprogramming01:29

Somatic to iPS Cell Reprogramming

Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...
Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.

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相关实验视频

Updated: May 13, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
12:12

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

通过三种方法将核重编程转变为多能状态.

Shinya Yamanaka1, Helen M Blau

  • 1Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan.

Nature
|June 11, 2010
PubMed
概括

成人细胞可以被重新编程成不同的细胞类型,显示出显著的细胞可塑性. 这种通过各种方法实现的重编程,对未来的医疗应用具有前景.

科学领域:

  • 细胞和分子生物学 细胞和分子生物学
  • 发育生物学 发展生物学
  • 再生医学是一种再生医学.

背景情况:

  • 分化细胞的稳定状态是动态控制的,容易受到干扰.
  • 细胞重编程允许成年细胞改变基因表达和细胞命运.

研究的目的:

  • 探索细胞重编程的机制和影响.
  • 突出诱导细胞可塑性的潜在医学应用.

主要方法:

  • 核转移 核转移是指进行核转移.
  • 细胞融合是细胞的融合.
  • 转录因子转导的转录因子.

主要成果:

  • 证明"终端分化"的体细胞核可以被重新编程.
  • 在重新编程的体细胞中显示胚胎干细胞基因的诱导表达.
  • 证实了重新编程的细胞有潜力分化为各种细胞类型.

结论:

  • 细胞可塑性是分化细胞的关键特征,使其能够进行重编程.
  • 核转移,细胞融合和转导等实验方法有效地诱导了重编程.

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RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
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RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

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Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
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Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

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相关实验视频

Last Updated: May 13, 2026

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors
12:12

In vivo Reprogramming of Adult Somatic Cells to Pluripotency by Overexpression of Yamanaka Factors

Published on: December 17, 2013

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells
11:38

RNA-based Reprogramming of Human Primary Fibroblasts into Induced Pluripotent Stem Cells

Published on: November 26, 2018

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations
10:45

Double In Utero Electroporation to Target Temporally and Spatially Separated Cell Populations

Published on: June 14, 2020

  • 细胞重编程为医学进步和治疗提供了巨大的潜力.