嗅觉神经元轴突对Sema3F的顺序到来和分级分泌确定了灯泡中的地图拓
Haruki Takeuchi1, Kasumi Inokuchi, Mari Aoki
1Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Tokyo 113-0032, Japan.
Cell
|June 17, 2010
概括
神经平素-2 (Nrp2) 和三林-3F (Sema3F) 指导嗅觉神经元 (OSN) 的轴突. 通过OSN对Nrp2和Sema3F的补充表达,在嗅球中建立了嗅觉地图拓.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 分子生物学分子生物学
背景情况:
- 小鼠的嗅觉感官神经元 (OSN) 将轴突投射到嗅球 (OB) 中的特定位置.
- OB的背腹 (D-V) 轴显示了OSN解剖位置和轴突投射位之间大致的相关性.
- 了解控制这种地形绘制的分子机制对于嗅觉系统的发展至关重要.
研究的目的:
- 为了研究神经平素-2 (Nrp2) 和三林-3F (Sema3F) 在建立嗅觉地图拓学的作用.
- 阐明OSN对这些分子的互补表达如何有助于轴突引导.
主要方法:
- 在OSNs中分析Nrp2和Sema3F的基因表达模式.
- 研究OSN轴突到达OB的时间动态.
- 利用遗传和分子技术来评估Nrp2和Sema3F对轴突突出的影响.
主要成果:
- Nrp2受体和Sema3F连接体通过OSNs以互补的方式表达.
- 塞马3F由早期到达的OSN轴突分泌,并驱逐晚些时候到达的Nrp2-阳性轴突.
- 顺序的轴突到来和Nrp2/Sema3F的分级表达是D-V地形绘制的关键.
结论:
- Nrp2和Sema3F之间的互补表达和排斥相互作用对于形成嗅觉拓地图至关重要.
- 随着OSN轴突的顺序到来,加上分子线索,决定了沿着OB的D-V轴的精确轴突准.
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