相关实验视频
血清B维生素水平和肺癌的风险
Mattias Johansson1, Caroline Relton, Per Magne Ueland
1International Agency for Research on Cancer, Lyon, France.
JAMA
|June 17, 2010
概括
血清维生素B6和甲因水平升高与肺癌风险降低有关. 这些发现表明,这些1碳代谢因子在预防肺癌方面可能发挥作用.
科学领域:
- 营养生物化学 营养生物化学
- 癌症流行病学癌症流行病学
- 分子生物学分子生物学
背景情况:
- 维生素B和1碳代谢因子对DNA完整性和基因表达至关重要.
- 这些因素可能会影响包括肺癌在内的癌症风险.
研究的目的:
- 为了检查1碳代谢因子和肺癌发病率之间的关联.
- 研究特定的B族维生素和相关代谢物在肺癌发展中的作用.
主要方法:
- 利用了欧洲前性癌症和营养调查 (EPIC) 队列 (n=385,747) 的数据.
- 测量了维生素B6,叶酸,维生素B12,氨酸和同类半氨酸的血清水平.
- 匹配了899例肺癌病例与1770例对照病例,分析了基于代谢物水平的肺癌风险概率比率.
主要成果:
- 较高的血清维生素B6水平与显著降低的肺癌风险相关 (OR,0.44).
- 血清氨酸的升高也显示出与肺癌风险的强烈反向关联 (OR,0.52).
- 结合高水平的维生素B6和氨酸进一步降低了肺癌风险 (OR,0.41).
结论:
- 血清维生素B6和氨酸水平与肺癌风险相反相关.
- 这些发现凸显了充足的B族维生素和氨酸状态对肺癌的潜在保护作用.
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