在无症状的退行性 mitrale 吐中运动肺高血压
Julien Magne1, Patrizio Lancellotti, Luc A Piérard
1Department of Cardiology, Heart Valve Disease Clinic, University Hospital Sart Tilman, University of Liège, Belgium.
Circulation
|June 23, 2010
概括
运动性肺高血压 (PHT) 是常见的在患有退行性部吐的患者. 额头回严重程度增加预测运动PHT,这与无症状存活率降低有关,并预测症状发作.
科学领域:
- 心脏病学 心脏病学
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
- 膜心脏疾病 膜心脏疾病
背景情况:
- 目前的指导方针建议对无症状的严重退行性 mitrales 吐,保持 LV 功能和运动肺高血压 (PHT) 进行 mitrales 门手术.
- 在这些患者中,运动PHT的决定因素仍未评估.
研究的目的:
- 在患有退行性心回的患者中确定运动PHT的心声预测因子.
- 评估运动PHT对症状和生存的影响.
主要方法:
- 78名患有中度至重度退行性 mitrale 吐的患者接受了休息和运动 transthoracic 心声图.
- 运动性肺高血压 (PHT) 被定义为静缩性肺动脉压 (SPAP) >60 mm Hg.
- 使用多变量分析和ROC曲线来识别预测因素并评估准确性.
主要成果:
- 运动PHT在46%的患者中存在.
- 运动有效的吐孔是运动SPAP和PHT的独立决定因素.
- 休息和运动PHT都与减少2年无症状生存率有关.
- 运动PHT独立预测症状发生 (HR=3.4,P=0.002).
结论:
- 运动PHT在无症状的退行性心肌吐中很常见.
- 运动中部反的严重程度预测了运动SPAP和PHT.
- 运动PHT显著降低了无症状生存率,并准确地预测了症状发作,突出了运动心声谱的价值.
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