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使用中的代谢前体进行选择性成像的策略

Pamela V Chang1, Danielle H Dube, Ellen M Sletten

  • 1Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, California 94720, USA.

Journal of the American Chemical Society
|June 24, 2010
PubMed
概括

研究人员开发了一种用于组织特异性甘氨酸成像的新方法,使用由酶激活的化代谢前体. 这种方法使前列腺特异性标签能够用于先进的研究和临床应用.

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Oligosaccharide Assembly01:24

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Protein glycosylation starts in the ER lumen and continues in the Golgi apparatus. Glycosyltransferases catalyze the addition of sugar molecules or glycosylation of proteins. Usually, these enzymes add sugars to the hydroxyl groups of selected serine or threonine residues to form O-linked glycans or the amino groups of asparagine residues to form N-linked glycans. Different positions on the same polypeptide chain can contain differently linked glycans.
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