细胞死亡期间自的激活需要吞受体Draper受体
Christina K McPhee1, Mary A Logan, Marc R Freeman
1Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Nature
|June 26, 2010
概括
德拉珀 (Drpr) 对于Drosophila唾液腺中编程细胞死亡期间的自是必不可少的,它与与生存相关的自区分开来. 这种吞因子在垂死的细胞内是必要的,以便它们自我清除.
科学领域:
- 细胞生物学 细胞生物学
- 发育生物学 发展生物学
- 自学研究 自学研究
背景情况:
- 自对于饥饿期间的细胞生存至关重要,但其在细胞死亡中的作用尚未完全理解.
- 区分细胞死亡期间的自与细胞存活期间的自是细胞生物学中的一个关键挑战.
- 德洛索菲拉的唾液腺经历了涉及自的编程细胞死亡,没有明显的细胞吞.
研究的目的:
- 调查Draper (Drpr) 在编程细胞死亡过程中的自中所扮演的角色.
- 要确定Drpr是否区分与细胞死亡和细胞存活相关的自.
- 为了确定调节死亡细胞自我清除的因素.
主要方法:
- 使用了Drosophila melanogaster模型,具有零突变和唾液腺特异性drpr基因的淘汰.
- 评估了drpr突变体的唾液腺降解和自诱导.
- 研究了drpr knockdown对脂肪体中饥饿诱导的自的作用.
- 研究了吞途径组件在垂死唾液腺清除中的要求.
主要成果:
- 无突变和drpr的淘汰抑制了唾液腺降解和细胞死亡期间自诱导.
- 在垂死的唾液腺细胞中,DRpr是需要用于自诱导和自我清除的.
- 减少DRpr并没有阻碍脂肪体中饥饿诱导的自,这与细胞存活有关.
- 吞通路的组成部分是必要的,以清除垂死的唾液腺.
结论:
- 在Drosophila唾液腺中,Draper (Drpr) 在编程细胞死亡和细胞自我清除期间对于自是必不可少的.
- Drpr作为第一个识别的因素,将与细胞死亡相关的自与与细胞存活相关的自区分开来.
- 这项研究揭示了吞因子在死亡细胞的非细胞自我清除中的新作用.
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