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Updated: Aug 12, 2026
14:19
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
Published on: October 14, 2016
在慢性冠状动脉封闭后,狗心肌肌蛋白酶异酶
S W Sharkey1, M M Murakami, S A Smith
1Cardiology Division, Hennepin County Medical Center, Minneapolis, Minn. 55415.
Circulation
|July 1, 1991
概括
慢性冠状动脉封闭显著增加心肌肌激酶-MB (CK-MB) 在受影响的心脏组织. 这种生化变化发生得很快,并且在地理上是特定的,而与超结构性损伤无关.
科学领域:
- 生物化学 生物化学
- 心脏病学 心脏病学
- 缺血症研究 缺血症研究
背景情况:
- 肌酸激酶 (CK) 包含多种异酶 (CK-MM,CK-MB,CK-BB,线粒体).
- 已知心肌中枢CK-MB是动态的,对缺血反应敏捷.
- 慢性冠状动脉封闭对心肌中枢CK系统的影响尚不清楚.
研究的目的:
- 为了研究慢性冠状动脉封闭后心肌CK异酶的连续变化.
- 为了确定生化变化是否与缺血性心肌中的超结构变化相关.
主要方法:
- 在冠状动脉堵塞之前和3周后,对狗心肌中总CK,百分比CK-MB和百分比CK-BB的连续测量.
- 来自LAD,RCA和环动脉区域的组织活检.
- 电子显微镜以评估缺血性肌肉病变.
主要成果:
- 整体心肌CK活性在3周内保持不变.
- 百分比CK-MB显著增加 (4.1-6.7倍) 在由封闭动脉供应的心肌中.
- 百分比CK-BB没有显著变化;超结构性肌病变化仅在LAD闭塞犬中观察到.
结论:
- 慢性冠状动脉封闭导致心肌中心脏CK系统中显著的局部生物化学变化.
- 心肌中CK-MB含量是动态的,表现出地理差异,并且在闭塞后迅速增加.
- 生物化学变化与观察到的细胞超结构变化没有相关性.
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