发现了一个proneurogenic,神经保护化学物质的发现
Andrew A Pieper1, Shanhai Xie, Emanuela Capota
1Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9152, USA. andrew.pieper@utsouthwestern.edu
Cell
|July 7, 2010
概括
一种新型化合物,P7C3,通过防止细胞死亡,促进成人海马中的新神经元生长. 这一发现为治疗影响记忆和大脑功能的神经系统疾病提供了潜在的可能性.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 成年海马神经发生对于学习和记忆至关重要.
- 神经发生的缺陷与认知衰退和神经系统疾病有关.
- 识别促进神经发生的化合物是一个关键的治疗目标.
研究的目的:
- 选增强成人海马神经发生的小分子.
- 为了研究有前途的化合物的作用机制.
- 在神经发育和与衰老有关的认知缺陷模型中评估已识别的化合物的治疗潜力.
主要方法:
- 在成年小鼠中对1000个小分子进行体内查.
- 化合物的药理特征,包括P7C3.3.
- 评估神经发生,神经元亡和野生类型和npas3(-/-) 小鼠的认知功能.
- 在老老鼠中对P7C3的评估.
主要成果:
- 1000种化合物中的8种增强了牙状环中的神经发生.
- P7C3,一种aminopropyl carbazole,表现出有利的药理特性,并保护新生儿的神经元免受亡.
- 给予P7C3可纠正海马神经发生缺陷和功能障碍在npas3(-/-) 小鼠中.
- 在老老鼠中,P7C3增强了神经发生,减少了神经元死亡,并保留了认知功能.
结论:
- P7C3 是成人海马神经发生的强有力的促进者.
- P7C3保护新生儿的神经元免受亡,这是其前神经元活动的关键机制.
- P7C3对神经发生障碍和认知能力下降的特征有治疗潜力.
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