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Updated: Aug 18, 2026

High-resolution Single Particle Analysis from Electron Cryo-microscopy Images Using SPHIRE
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重组的人类类类风湿性关节炎综膜液脂酶A2在2.2A分辨率的结构

J P Wery1, R W Schevitz, D K Clawson

  • 1Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285.

Nature
|July 4, 1991
PubMed
概括

分泌脂酶A2 (s-PLA2) 酶与炎症有关. 研究人员确定了人类类类风湿性关节炎突液s-PLA2的3D晶体结构,有助于设计向抑制剂.

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Assembly of the Lipid Bilayer in the ER01:28

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Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...