海洋omega-3脂肪酸对心血管的影响
Palaniappan Saravanan1, Neil C Davidson, Erik B Schmidt
1Cardiovascular Research Group, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK. drplsuk@yahoo.co.uk
Lancet (London, England)
|July 20, 2010
概括
海洋omega-3脂肪酸对心脏有好处,但它们与其他治疗方法的有效性和最佳剂量需要进一步研究. 潜在的促节律失常效应也需要调查.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 海洋omega-3脂肪酸,eicosapentaenoic acid (EPA) 和docosahexaenoic acid (DHA),已被认为具有对心血管的有益作用.
- 在心肌梗塞后的患者中,指导方针建议服用omega-3.
- 关于它们与最佳医疗疗法并肩的有效性以及潜在的前节律失常效应存在新出现的问题.
研究的目的:
- 审查有关心脏病中omega-3多不和脂肪酸 (PUFA) 的现有证据.
- 评估omega-3PUFAs在心脏病风险因素中的作用.
- 确定不确定性和未来研究领域.
主要方法:
- 科学文献的系统审查.
- 分析临床试验数据和观察性研究.
- 评估有关剂量,饮食摄入量与补充剂以及安全性概况的证据.
主要成果:
- 在某些心脏疾病中,欧米茄-3 PUFA 的已知益处.
- 当与现代心脏保护药物一起使用时,对益处的不确定性.
- 有证据表明,在特定患者群体中存在潜在的前节律失常风险.
结论:
- 欧米茄-3脂肪酸在当代心脏护理中的作用需要进一步澄清.
- 最佳剂量和饮食来源和补充剂之间的平衡仍然是研究领域.
- 需要进一步的研究,以充分了解高风险心脏病患者的omega-3PUFAs的风险益处概况.
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