在扩展的多中心美国旋律试验中,通过导管放置肺后的短期和中期结果
Doff B McElhinney1, William E Hellenbrand, Evan M Zahn
1Department of Cardiology, Children's Hospital Boston, Boston, Mass 10032, USA.
Circulation
|July 21, 2010
概括
使用Melody的透管肺替换显示出高的程序成功率,并改善了肺吐患者的短期功能. 谨慎的患者选择和管理右心室外流通道阻塞对于最佳结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 医疗器械 医疗器械
背景情况:
- 透导管肺放置是一种新兴的治疗方法,用于肺吐和右心室外流通道阻塞.
- 旋律在美国被批准用于功能障碍的右心室外流管道.
研究的目的:
- 报告一项多中心试验的最新结果,该试验是用于跨导管肺置换的Melody.
- 评估手术成功,短期门功能,以及与Melody门植入相关的并发症.
主要方法:
- 总共有136名患者在5个中心接受了用于预期的Melody植入的导管治疗.
- 在124名患者中尝试植入;由于冠状动脉压缩风险等禁忌,12名患者被排除在外.
- 收集和分析了手术成功,门功能和并发症的数据.
主要成果:
- 程序的成功率很高,右心室外流通道梯度和肺反的显著减少.
- 在所有患者中,早期植入后的肺反是轻微的.
- 一年后,Melody门功能障碍或重新干预的自由率为93.5%;在14个月后,22.2%的患者发生了支架骨折.
结论:
- 梅洛迪门试验证明了高的程序成功,并鼓励短期门功能.
- 重新干预主要针对右心室外流通道阻塞,强调患者选择和阻塞管理.
- 预防和管理支架骨折对于长期门耐用性至关重要.
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