抗糖尿病药物可以通过Cdk5抑制与肥胖相关的PPARgamma的酸化

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Jang Hyun Choi1, Alexander S Banks, Jennifer L Estall

  • 1Department of Cancer Biology and Division of Metabolism and Chronic Disease, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.

Nature
|July 24, 2010
PubMed
概括

高脂肪饮食激活Cdk5,在脂肪组织中化PPARgamma. 这会扰乱基因表达,并降低阿迪波内克丁,导致胰岛素抵抗. 阻止这种酸化可能会提供新的抗糖尿病治疗方法.

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