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死产和新生儿死亡与受孕前的辐射暴露有关:一个回顾性队列研究
Lisa B Signorello1, John J Mulvihill, Daniel M Green
1International Epidemiology Institute, Rockville, MD 20850, USA. lisa@iei.us
Lancet (London, England)
|July 27, 2010
概括
在童年幸存者中,放射和化疗等癌症治疗没有增加子女死产或新生儿死亡风险,除了子宫和卵巢辐射外,这些辐射显示出不良影响. 建议在青春期前接受盆腔辐射的妇女谨慎进行怀孕管理.
科学领域:
- 生殖健康 生殖健康
- 儿科瘤学 儿科瘤学
- 遗传学 是一个遗传学.
背景情况:
- 治疗儿童癌症幸存者的生殖结果仍然不清楚.
- 评估怀孕风险间接评估生殖线损害传播给后代的情况.
研究的目的:
- 为了确定儿童癌症幸存者的后代中死产和新生儿死亡的风险.
- 调查特定癌症治疗 (放射治疗,化疗) 与不良妊娠结果之间的关联.
主要方法:
- 从儿童癌症幸存者研究 (CCSS) 中对1148名男性和1657名女性儿童癌症幸存者的回顾性队列分析.
- 对丸,卵巢,子宫和垂体腺体的量化化疗暴露和预孕辐射剂量.
- 使用波桑回归来分析死胎或新生儿死亡的风险.
主要成果:
- 丸,垂体辐射和化疗与增加死产或新生儿死亡无关.
- 子宫和卵巢辐射 (≥10.00 Gy) 显著增加了风险.
- 在初潮前接受治疗的女性中,低剂量子宫/卵巢辐射 (1.00-2.49 Gy) 也增加了风险.
结论:
- 没有证据表明遗传性遗传变化影响后代的存活力,来自男性淋巴腺辐射.
- 子宫和卵巢辐射对后代构成重大风险,可能是由于子宫损伤.
- 在青春期之前暴露于高剂量盆腔辐射的妇女,怀孕管理需要谨慎注意.
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