心脏正子发射断层扫描/计算机断层扫描成像准确检测解剖学和功能上显著的冠状动脉疾病
S Kajander1, E Joutsiniemi, M Saraste
1Turku PET Centre, Turku, Finland.
Circulation
|July 28, 2010
概括
混合正子发射断层扫描 (PET) /CT精确检测冠状动脉疾病. 这种非侵入性成像方法结合了CT血管造影和 perfusion 成像,以提高低辐射剂量的诊断准确性.
科学领域:
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
- 核医学就是核医学.
背景情况:
- 计算机断层扫描 (CT) 被广泛用于冠状动脉疾病 (CAD) 的检测,但狭窄的评估可能是不确定的.
- 输液成像对于识别缺血和指导治疗至关重要.
- 混合正子发射断层扫描 (PET) /CT提供了高效,定量,低剂量协议的结合血管造影和 perfusion 成像.
研究的目的:
- 评估心脏混合PET/CT用于冠状动脉疾病的非侵入性检测的准确性.
- 为了比较混合PET/CT与CT血管造影和输液成像单独对抗侵入性血管造影的诊断性能.
主要方法:
- 107名患有中等预测可能患有CAD的患者接受了使用混合PET/CT的定量PET/(15) O水和CT血管造影.
- 结果与侵入性血管造影进行了验证,包括部分流量储备测量,如适用.
- 记录了潜在触发和螺旋CT协议的辐射剂量.
主要成果:
- 混合PET/CT在检测冠状动脉疾病方面实现了98%的准确性,单独CT血管造影 (81%PPV) 和单独 perfusion 成像的表现明显优于.
- 两种PET/CT和CT血管图都显示了97%的负预测值.
- 辐射剂量很低,潜在触发协议的平均值为9.3mSv.
结论:
- 心脏混合PET/CT可在有症状的个体中提供冠状动脉疾病的准确非侵入性诊断.
- 这种成像模式在常规临床使用中是可行的.
- 大多数患者可以在不到10mSv的辐射暴露下进行手术.
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