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相关概念视频

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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相关实验视频

Updated: Jun 10, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

来自自燃聚合物的可编程微囊.

Aaron P Esser-Kahn1, Nancy R Sottos, Scott R White

  • 1Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|July 29, 2010
PubMed
概括
此摘要是机器生成的。

可编程的微囊是使用自燃聚合物开发的. 这些智能囊只在特定的化学触发器移除末端组时释放内容,从而实现受控材料修复.

更多相关视频

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
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Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

相关实验视频

Last Updated: Jun 10, 2026

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches
10:07

Preparation of Multifunctional Silk-Based Microcapsules Loaded with DNA Plasmids Encoding RNA Aptamers and Riboswitches

Published on: October 8, 2021

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation
06:57

Rapid, Scalable Assembly and Loading of Bioactive Proteins and Immunostimulants into Diverse Synthetic Nanocarriers Via Flash Nanoprecipitation

Published on: August 11, 2018

科学领域:

  • 材料科学 材料科学 材料科学
  • 聚合物化学 聚合物化学
  • 化学工程是化学工程的重要组成部分.

背景情况:

  • 损坏的材料的自主修复需要先进的输送系统.
  • 目前的微囊通常依赖于机械破裂来释放内容.
  • 存在对具有可编程,刺激响应释放机制的微囊的需求.

研究的目的:

  • 开发一种用于制造可编程微囊的通用方法.
  • 设计微囊,以响应特定的化学触发器释放内容,而不仅仅是机械力.
  • 为了证明这些新型微囊的受控释放能力.

主要方法:

  • 核心外微囊与自燃聚合物网络的合成.
  • 将特定的触发端组 (Boc和Fmoc) 纳入聚合物外.
  • 在各种化学条件下测试微囊的稳定性和触发释放.

主要成果:

  • 成功制造了具有自燃聚合物外的可编程微囊.
  • 证明微囊的释放内容仅在移除特定的触发端组 (Boc/Fmoc) 时才会发生.
  • 在暴露于触发条件时观察到外壁的物理裂,支持脱聚合机制.

结论:

  • 已经建立了一条基于自燃聚合物的可编程微囊的多功能途径.
  • 这些微囊提供受控的内容释放,由特定的化学刺激触发.
  • 开发的技术有望用于自主材料修复和先进药物输送的应用.