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人类β2上腺素受体逆agonists和对手的保留结合方式被X射线晶体学揭示

Daniel Wacker1, Gustavo Fenalti, Monica A Brown

  • 1Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|July 31, 2010
PubMed
概括

对β2上腺素受体 (β2AR) 的结构研究显示,当它与不同的逆agonists和antagonists结合时,会发生轻微的局部变化. 这些发现有助于理解用于药物设计的配体相互作用.

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