脊椎动物第二心脏场的早期弦状细胞起源
Alberto Stolfi1, T Blair Gainous, John J Young
1Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA.
概括
这项研究揭示,简单的带状心脏前代细胞形成心房吸管肌肉的前体,与脊椎动物第二心场 (SHF) 前代共享基因表达. 这表明心肌有着共同的进化起源.
科学领域:
- 发育生物学是发展生物学.
- 进化发育生物学 进化发育生物学
- 带状胚胎学 带状胚胎学
背景情况:
- 脊椎动物的心脏从不同的胚胎区域发育,包括第一个和第二个心脏场 (SHF).
- SHF对于形成右心室和流出通道至关重要,但它的进化历史在很大程度上是未知的.
研究的目的:
- 调查第二个心脏场 (SHF) 的进化起源.
- 在更简单的带状动物中确定同源的发育途径,这可能会揭示脊椎动物心脏进化.
主要方法:
- 使用简单的带体Ciona intestinalis进行比较胚胎学.
- 对心脏前代细胞中的基因表达模式的分析.
- 研究转录因子 (如COE) 的作用.
主要成果:
- 在Ciona intestinalis中的心脏原生细胞产生心房吸管肌肉 (ASM) 的前体.
- 这些前体呈现基因表达 (Islet, Tbx1/10) 类似于脊椎动物脊柱状半皮和SHF.
- 转录因子COE被确定为ASM命运的关键调节者.
结论:
- 提出了多能心肌前体存在于衣动物和脊椎动物的最后一个共同祖先.
- 表明这些前体的重新分配可能对脊椎动物SHF的进化起到了重要作用.
相关概念视频
Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Chambers of the Heart
The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
Deoxygenated blood from the body is received in the right...
Development of Blood Vessels
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
Development of the Lymphatic System
The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...


