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Updated: May 11, 2026

Assaying the Kinase Activity of LRRK2 in vitro
06:09

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Published on: January 18, 2012

致病性LRRK2负面调节微RNA介导的翻译抑制

Stephan Gehrke1, Yuzuru Imai, Nicholas Sokol

  • 1Department of Pathology, Stanford University School of Medicine, Stanford, California 94305, USA. sgehrke@stanford.edu

Nature
|July 31, 2010
PubMed
概括

氨酸丰富的重复激酶2 (LRRK2) 的功能增益突变通过损害微RNA (miRNA) 途径导致帕金森病. 这导致E2F1/DP的过度生产,导致神经退行,并建议基于miRNA的疗法.

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