心脏指数与大脑衰老有关:弗雷明翰心脏研究
Angela L Jefferson1, Jayandra J Himali, Alexa S Beiser
1Department of Neurology, Alzheimer's Disease Center, Boston University School of Medicine, 72 E Concord St, B-7800, Boston, MA 02118, USA. angelaj@bu.edu
Circulation
|August 4, 2010
概括
降低心脏功能,即使在正常范围内,也与加速的大脑衰老有关. 较低的心脏指数与较小的大脑体积和老年人的处理速度较慢相关.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 老年学是指老年学的学科.
背景情况:
- 心脏功能障碍与心血管疾病的老年人中神经解剖学和神经心理学变化有关.
- 低输液可能会扰乱大脑输液,导致亚临床大脑损伤.
- 这项研究调查了心脏功能和临床前大脑标志物之间的关联.
研究的目的:
- 测试通过心脏指数测量的心脏功能与临床前大脑MRI和神经心理标志物相关的假设.
- 探索心脏指数和缺血和阿尔茨海默病的标志物之间的关系.
主要方法:
- 研究了1504名没有中风,TIA或痴呆症的Framingham后代队列参与者 (年龄为61±9岁,54%为女性).
- 收集了脑部MRI,心脏MRI,神经心理测试和实验室数据.
- 心脏指数 (心脏输出/身体表面积) 与大脑MRI和神经心理变量有关.
主要成果:
- 较高的心脏指数与大脑总体体积和信息处理速度有积极的关联.
- 较高的心脏指数与侧腔室体积相反相关.
- 心脏指数和总大脑体积之间的关联在排除患有心血管疾病的参与者之后仍然存在.
结论:
- 降低心脏功能,即使在正常心脏指数水平,也与加速的大脑衰老有关.
- 这些发现支持了将心脏功能与大脑衰老联系在一起的假设.
- 观察数据表明存在关联,尽管无法确定因果关系.
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