快速释放被困的内容从多功能,表面交叉连接的细胞在不同的刺激后迅速释放
1Department of Chemistry, Iowa State University, Ames, Iowa 50011-3111, USA.
Journal of the American Chemical Society
|August 5, 2010
概括
研究人员开发了一种点击化学方法,以在纳米粒子中捕获疏水分子. 这些纳米颗粒在交叉连接器被切割后迅速释放它们的载荷,显示出药物输送的潜力.
科学领域:
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 在水系统中对疏水分子的封装具有挑战性.
- 封装物质的控制释放需要精确的触发器.
- 点击化学提供高效和特定的分子结合.
研究的目的:
- 开发一种用于纳米粒子中封装疏水客的新方法.
- 为引发货物释放设计具有可切割交叉链接器的纳米粒子.
- 评估该系统在药剂输送方面的潜力.
主要方法:
- 利用一种基化表面活性剂和一种化物功能化的交叉链接剂,通过点击反应形成纳米粒子.
- 设计的交叉连接器包含可切割键 (双二醇,二硫化物,乙).
- 研究了在稀释时低于临界微粒度 (CMC) 的纳米粒子行为,并触发了交叉连接器裂变.
主要成果:
- 成功地将疏水性客分子 (例如,pyrene) 困在表面活性剂小粒体内.
- 形成的水溶性纳米粒子在稀释后呈现静电应力.
- 在交叉连接器裂变时实现极快 (<1分钟) 的疏水含量释放.
结论:
- 开发的方法有效地将物理捕获与化学结合结合起来,以形成纳米粒子.
- 可切割的交叉连接器可以准确和快速触发封装的疏水性客人的释放.
- 这种方法对先进的药物输送和受控释放应用具有重大前景.
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