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Updated: Jun 10, 2026

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
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在1p13胆固醇位点通过SORT1从非编码变异转变为表型

Kiran Musunuru1, Alanna Strong, Maria Frank-Kamenetsky

  • 1Cardiovascular Research Center and Center for Human Genetic Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.

Nature
|August 6, 2010
PubMed
概括

接近SORT1基因的常见遗传变异通过改变肝脏如何产生非常低密度脂蛋白颗粒来影响胆固醇水平和心脏病发作风险. 这一发现揭示了管理脂蛋白代谢和心血管疾病风险的新途径.

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