相关实验视频
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Published on: June 6, 2020
怀孕体重增加与出生体重之间的关联:家庭内部比较
1Department of Medicine, Children's Hospital, Boston, MA 02115, USA. david.ludwig@childrens.harvard.edu
Lancet (London, England)
|August 10, 2010
概括
在怀孕期间母亲过度体重增加与高出生体重有关,独立于遗传学. 这表明怀孕体重管理可能有助于预防儿童肥胖.
科学领域:
- 产科和妇科 产科和妇科
- 儿科 儿科 儿科
- 公共卫生 公共卫生
背景情况:
- 过度的妊娠体重增加与后代出生体重增加和晚年肥胖风险增加有关.
- 遗传和共同的环境因素可能会混观察到的关联.
- 使用兄弟数据的课题内设计可以帮助减轻混.
研究的目的:
- 为了研究母亲体重增加和后代出生体重之间的关联.
- 要确定这种关联是否独立于遗传因素.
- 为针对孕妇的肥胖预防策略提供信息.
主要方法:
- 基于人口的队列研究,使用密歇根州和新泽西州的出生登记数据 (1989-2003).
- 包括多次单独分娩的妇女,不包括早产或产后妊娠,孕产妇糖尿病和极端出生体重.
- 利用一个主体内部设计来比较来自同一母亲的后代的出生体重与不同的怀孕体重增加.
主要成果:
- 分析包括来自513,501名妇女的110多万次分娩.
- 在母亲体重增加和出生体重 (β = 7.35,p<0.0001) 之间发现了显著的关联.
- 体重>24公斤的妇女的婴儿体重增加了148.9克;出生体重>4000克的几率是体重增加8-10公斤的妇女的2.26倍.
结论:
- 怀孕期间母亲的体重增加独立增加后代的出生体重.
- 研究结果表明,管理妊娠期体重增加的干预措施可能对预防儿童肥胖至关重要.
- 专注于怀孕期间健康体重增加的公共卫生倡议是有必要的.
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