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Updated: Jun 10, 2026

The use of SC1 (Pluripotin) to Support mESC Self-renewal in the Absence of LIF
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Published on: November 18, 2009

Plzf通过对抗mTORC1来调节生殖系祖先的自我更新

Robin M Hobbs1, Marco Seandel, Ilaria Falciatori

  • 1Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.

Cell
|August 10, 2010
PubMed
概括

过度活跃的mTORC1信号通过破坏利基信号来消耗干细胞. 转录因子Plzf通过抑制mTORC1来维持干细胞池,这对精子前代细胞更新至关重要.

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