发育中的人类心脏静脉极的三维和分子分析
Aleksander Sizarov1, Robert H Anderson, Vincent M Christoffels
1Heart Failure Research Center, Academic Medical Center, Amsterdam, the Netherlands.
Circulation
|August 11, 2010
概括
人类心脏发育揭示了系统性和肺静脉心肌的不同起源. 人类和小鼠之间的基因表达相似性允许将小鼠研究结果应用于人类胚胎发育.
科学领域:
- 心血管系统的发展.
- 人类胚胎学 人类胚胎学
- 分子心脏病学分子心脏病学
背景情况:
- 先天性心脏形和心律失常常常来自心脏的静脉极.
- 人类静脉极的发育是复杂的,原因是快速的形态发生和有限的分子数据.
- 了解这个区域对于解决心脏先天缺陷至关重要.
研究的目的:
- 为了研究人类心脏静脉极心肌的发育起源.
- 为了比较人类静脉极的发育与老鼠.
- 在发育中的人类心脏中识别出不同的心肌系.
主要方法:
- 人类胚胎 (22-40天妊娠期) 的免疫组织化学分析.
- 连续胚胎心脏部分的三维重建和分析.
- 用小鼠模型对基因表达模式 (TBX18,NKX2-5) 的比较分析.
主要成果:
- 系统静脉心肌表达TBX18;肺静脉心肌表达NKX2-5,类似于小鼠.
- 系统性静脉鼻形成在心房的上游,最初缺乏心肌壁.
- 肺静脉连接到类似心房的腔室,前庭脊柱突出.
- 交互式3D模型促进了复杂的形态遗传变化的空间解释.
结论:
- 在人类中,不同的发育谱系导致了全身和肺静脉心肌袖.
- 基因表达的相似性支持将小鼠血统和转基因研究结果推断为人类发展.
- 这项研究阐明了心肌结构在人心静脉极的起源.
更多相关视频
06:48Three-Dimensional Echocardiographic Method for the Visualization and Assessment of Specific Parameters of the Pulmonary Veins
Published on: October 28, 2020
04:29Three-Dimensional Modeling of the Left Atrium and Pulmonary Veins with a Precise Intracardiac Echocardiography Approach
Published on: June 30, 2023
相关概念视频
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Anatomy of the Heart
The heart is a hollow, muscular organ approximately the size of a fist, consisting of four chambers. It is enclosed in the pericardium, a fibrous sac with two layers: the visceral and parietal pericardium, separated by a fluid-filled space containing serous fluid to reduce friction.
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
