出生体重是发生性心房的重要危险因素
David Conen1, Usha B Tedrow, Nancy R Cook
1Center for Arrhythmia Prevention, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass., USA. conend@uhbs.ch
Circulation
|August 11, 2010
概括
较高的出生体重与女性患心房的风险增加有关. 这表明早期生活因素可能会影响AF的发展.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 生殖健康 生殖健康
背景情况:
- 出生体重和心房动 (AF) 发生率之间的关系尚未得到充分研究.
- 心房动是一种常见的心律失常,具有重大公共卫生影响.
研究的目的:
- 调查出生体重与女性发生发生心房的风险之间的关联.
- 探索心房动的潜在早期生命决定因素.
主要方法:
- 一项前性队列研究跟踪了27,982名45岁以上的女性,在基线时没有心血管疾病和AF.
- 出生的体重被分类,事件AF被追踪了平均14.5年.
- 多变量考克斯回归模型被用来评估AF的风险比率跨出生体重类别,以各种因素进行调整.
主要成果:
- 出生体重较高的类别与发生性AF风险显著增加有关 (线性趋势的P=0.002).
- 在对BMI,血压和糖尿病进行调整后,这种关联仍然存在.
- 在模型中包括身高和年轻成年人体重减弱了观察到的关系.
结论:
- 出生体重是女性发生心房动的重要预测因素.
- 这些发现强调了早期生活因素在AF长期发展中的潜在作用.
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