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Updated: Jun 10, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

正式的 [2 + 2 + 2] 循环添加策略是基于分子内基酶反应/Diels-Alder循环添加级联

Julia M Robinson1, Takeo Sakai, Katsuhiko Okano

  • 1Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

Journal of the American Chemical Society
|August 12, 2010
PubMed
概括

本研究介绍了一种新的,无金属的 [2 + 2 + 2] 循环添加策略. 它利用一连串的循环反应,包括一个propargylic ene反应和一个Diels-Alder反应,以形成复杂的循环结构.

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[4+2] Cycloaddition of Conjugated Dienes: Diels–Alder Reaction

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Cycloaddition Reactions: MO Requirements for Thermal Activation

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