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焦虑气质的杏仁体和海马体基质在它们的遗传性上有所不同
Jonathan A Oler1, Andrew S Fox, Steven E Shelton
1Department of Psychiatry, University of Wisconsin-Madison, Madison, Wisconsin 53719, USA.
Nature
|August 13, 2010
概括
年轻子的焦虑性情 (AT) 与特定的大脑区域有关. 遗传因素影响海马,但不影响杏仁体,这表明各种遗传和环境影响焦虑风险.
科学领域:
- 神经科学是一个神经科学.
- 行为遗传学 行为遗传学
- 灵长类动物学 灵长类动物学
背景情况:
- 焦虑气质 (AT) 是一个预测精神病理学的早期生活特征.
- 了解AT的神经基础和遗传性对于早期干预至关重要.
- 导致儿童患上AT及其潜在大脑系统的因素尚不清楚.
研究的目的:
- 在 rhesus 子中描述 AT 的神经回路.
- 为了确定AT的遗传性及其相关的大脑活动.
- 研究对关键大脑区域的差异性遗传和环境影响.
主要方法:
- 研究了238只来自多代血统的年轻 rhesus 子.
- 使用高分辨率 (18) F标记的脱氧葡萄糖正子发射断层扫描 (FDG-PET) 评估大脑代谢活动.
- 同时测量行为和大脑活动在引起AT的伦理条件下.
主要成果:
- 杏仁体和前海马体的中央核是预测AT的关键神经元件.
- 发现AT表型和海马体代谢活性具有显著的遗传性.
- 预测AT的杏仁体活动没有显著的遗传性,不同地区的遗传性不同.
结论:
- 杏仁体和海马体在调解AT方面发挥着不同的作用.
- 不同的遗传和环境影响在AT中塑造了这些大脑区域.
- 研究结果强调了各种因素对焦虑和抑郁风险的贡献.
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