具有竞争力的碳-硫与碳-碳键激活2-cyanothiophene与[Ni(dippe) H]2的竞争性碳-硫与碳-碳键激活

Matthew R Grochowski1, Ting Li, William W Brennessel

  • 1Department of Chemistry, University of Rochester, Rochester, New York 14627, USA.

概括

这项研究使用化合物研究了C-C和C-S键裂变. 研究人员确定了关键的中间体和产品,揭示了对有机金属反应机制的洞察力.

相关概念视频

Catalysis02:50

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meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H01:13

meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for the...