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大人的一生中大动脉根重塑:来自弗雷明汉心脏研究的纵向数据
Carolyn S P Lam1, Vanessa Xanthakis, Lisa M Sullivan
1Framingham Heart Study, Framingham, MA 01702-5803, USA.
Circulation
|August 18, 2010
概括
大动脉根重塑发生在整个成年期,主要受到年龄,性别,体型和血压的影响. 这些因素会随着时间的推移影响大动脉的尺寸,因此需要进一步研究心血管事件的发展.
科学领域:
- 心血管医学 心血管医学
- 纵向衰老研究 纵向衰老研究
- 大动脉重塑大动脉重塑
背景情况:
- 大动脉根改造与心血管结果有关.
- 对成年人大动脉根重塑相关的纵向数据有限.
研究的目的:
- 为了跟踪大动脉根直径变化超过16年的成年期中期到晚期.
- 确定大动脉根重塑的短期和长期临床相关性.
主要方法:
- 使用了来自弗雷明汉心脏研究的连续回声心脏图.
- 在4年和16年间使用多级建模进行纵向分析.
- 分析了与年龄,性别,体型和血压的关联.
主要成果:
- 大动脉根直径随着年龄的增长而增加,男性更大,男性更大.
- 增加的体重指数与更大的大动脉根尺寸相关.
- 脉压升高与较小的大动脉根有关.
结论:
- 大动脉根的重塑是成年人的一个持续的过程.
- 年龄,性别,体型和血压是大动脉重塑的关键相关因素.
- 需要对机制和心血管影响进行进一步的研究.
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