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成年人患有手术修复的法洛特四重症:多机构研究中的心律失常负担
Paul Khairy1, Jamil Aboulhosn, Michelle Z Gurvitz
1Adult Congenital Heart Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada. paul.khairy@umontreal.ca
Circulation
|August 18, 2010
概括
患有Fallot四重症的成年人的心律失常负担很大,随着年龄的增长而增加. 左侧心脏病因素影响心房动和心室心律不整.
科学领域:
- 心脏病学 心脏病学
- 成年人的先天性心脏病
- 电子生理学 电子生理学
背景情况:
- 患有四重法洛特病 (ToF) 的成年人心律失常的患病率和风险可能随着年龄的增长而变化.
- 了解这些与年龄相关的趋势对于管理这个不断增长的人口至关重要.
研究的目的:
- 为了量化成人ToF患者的心律失常负担.
- 描述心律失常的与年龄相关的趋势.
- 为了确定与不同类型的心律失常亚型相关的因素.
主要方法:
- 这是一项多中心的横截面研究,涉及556名成年ToF患者 (平均年龄为36.8岁).
- 收集有关心律失常史,干预措施和临床因素的数据.
- 用于识别与特定心律失常相关的多变量分析.
主要成果:
- 43.3%的患者患有持续性心律失常或干预.
- 与右心房扩大和高血压相关的心房动脉节拍 (20.1%) .
- 与老年相关的心房动,较低的LVEF,左心房扩张和之前的手术.
- 与之前的手术,QRS持续时间和LV扩张功能障碍相关的静脉节律失常 (14.6%).
- 在45岁以后,心房动和心室节律失常的患病率显著增加.
结论:
- 患有ToF的成年人有相当大的心律失常负担.
- 不同的心律失常亚型具有不同的风险概况.
- 左侧心脏病指标是ToF中心房动和心室心律不整的重要因素.
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