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在与EGF受体结合的生长因子中负合作性的结构基础

Diego Alvarado1, Daryl E Klein, Mark A Lemmon

  • 1Department of Biochemistry and Biophysics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6059, USA.

Cell
|August 21, 2010
PubMed
概括

皮表皮生长因子受体 (EGFR) 结合表现出负合作性,其中第一个配体结合减少了随后结合的亲和力. 这解释了细胞表面EGF受体的特征和独特的信号特性.

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