保存的真菌LysM效应物Ecp6可以防止植物中基触发的免疫
Ronnie de Jonge1, H Peter van Esse, Anja Kombrink
1Laboratory of Phytopathology, Wageningen University, Droevendaalsesteeg 1, 6708 PB Wageningen, Netherlands.
概括
菌病原体Cladosporium fulvum使用效应蛋白Ecp6通过隔离基寡糖体来抑制宿主免疫力,防止与病原体相关的分子模式识别. 这种机制突出显示了真菌植物病原体中保存的免疫逃避策略.
科学领域:
- 植物病理学 植物病理学
- 免疫学 免疫学 免疫学
- 菌类学 菌类学是指菌类学.
背景情况:
- 多细胞生物拥有能够识别病原体相关分子模式 (PAMPs) 的免疫系统.
- 来自真菌细胞壁的基寡糖类,在植物和哺乳动物中充当PAMP,触发宿主免疫力.
- 病原体使用效应蛋白来抵消宿主免疫力并促进感染.
研究的目的:
- 调查Cladosporium fulvum中含有LysM域的效应蛋白Ecp6在毒性中的作用.
- 阐明Ecp6扰乱基触发宿主免疫力的机制.
主要方法:
- 研究了效应蛋白Ecp6.6的功能.
- 在真菌感染期间分析了Ecp6和基寡糖类之间的相互作用.
主要成果:
- Ecp6将从真菌菌根中释放出来的素寡糖分隔离.
- 这种隔离可以防止引起宿主免疫力,从而促进真菌的毒性.
- 像Ecp6这样的LysM效应器在各种真菌物种中广泛存在.
结论:
- 在宿主植物中,Ecp6通过干扰基触发的免疫来调节病毒性.
- Ecp6机制代表了由真菌病原体抑制免疫力的潜在常见策略.
- 保存的LysM效应器表明一种广泛的真菌免疫逃避策略.
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