在人类结核病中的干扰素诱导性中性粒细胞驱动的血液转录特征
Matthew P R Berry1, Christine M Graham, Finlay W McNab
1Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK.
Nature
|August 21, 2010
概括
这项研究确定了全血中新型基因表达特征,以诊断活性结核病 (TB) 并将其与其他疾病区分开来. 这些与免疫反应相关的生物标志物为改善结核病诊断和治疗提供了潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 基因组学就是基因组学.
- 传染性疾病 传染性疾病
背景情况:
- 结核病 (TB) 由于诊断,预防和治疗的困难,仍然是全球卫生挑战.
- 目前无法确定因潜伏感染而面临活跃结核病风险的个体.
- 对Mycobacterium tuberculosis的复杂免疫反应阻碍了新的干预措施的开发.
研究的目的:
- 为了确定全血基因表达特征,用于积极的结核病诊断.
- 发现能够区分活跃结核病与其他炎症和传染病的生物标志物.
- 探索免疫信号通路在结核病原发生过程中的作用.
主要方法:
- 在活跃结核病,潜伏结核病和健康对照人群中进行了全血转录基因分析.
- 分析了转录特征,以找出与疾病严重程度和治疗反应的相关性.
- 使用路径和模块化分析来了解已识别的签名的生物学基础.
- 与从全身性红斑狼 (SLE) 患者的转录数据进行了比较.
主要成果:
- 确定了393个活跃结核病的转录特征,在治疗后正常化.
- 一个独特的86个转录的签名准确地区分了活跃的结核病和其他疾病.
- 结核病特征的特征是中性粒细胞驱动的,干扰素 (IFN) 诱导的基因配置文件,包括IFN-和I型IFN-α/β信号.
- 细胞组成和基因表达的差异是由转录基因数据提出的.
结论:
- 新的全血转录组签名可以作为结核病的诊断和预后生物标志物.
- 这些发现凸显了IFN-alpha/beta信号传递在结核病发病过程中所扮演的角色被低估了.
- 这些生物标志物对开发新疫苗和治疗方法对抗结核病流行病有重大影响.
相关概念视频
Tuberculosis
Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:

