在动脉样硬化倾向的小鼠中,在动脉损伤后的新密度形成中准C5a受体
Erdenechimeg Shagdarsuren1, Kiril Bidzhekov, Sebastian F Mause
1Institute of Molecular Cardiovascular Research, RWTH Aachen University, Aachen, Germany.
Circulation
|August 25, 2010
概括
通过对抗剂或抗体阻断C5a受体 (C5aR),在受伤后的小鼠中减少了动脉新密度的形成和炎症. 然而,长期封锁稳定了斑块,这表明C5aR在血管重塑中的复杂作用.
科学领域:
- 心血管生物学 心血管生物学
- 免疫学 免疫学 免疫学
- 血管生物学 血管生物学
背景情况:
- 补充C5a受体 (C5aR) 调解了前炎性反应.
- 在创伤后动脉重塑中C5aR的作用仍然未被描述.
研究的目的:
- 调查C5aR在血管损伤后对新内形成的贡献.
- 在动脉样硬化小鼠模型中评估C5aR抗的疗效.
主要方法:
- 缺乏阿波利波蛋白E的小鼠经历了导线诱导的动脉脱皮.
- 小鼠接受了C5aR抗剂 (C5aRA) 或阻断抗体的治疗.
- 评估了neointima形成,细胞含量和分子标记物.
主要成果:
- 短期C5aRA或抗体治疗显著降低了neointima形成和炎症细胞透 (单细胞,中性粒细胞).
- 在血管光滑肌细胞中发现了C5aR表达,并且在受伤时被上调.
- C5aR阻塞降低了血管细胞粘附分子-1和等离子体激活剂抑制剂-1水平.
结论:
- 一周的C5aR阻断限制了新极端增生和炎症.
- 三周的治疗并没有减少,而是稳定了斑块,可能是通过促进血管光滑肌肉细胞迁移.
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