淋巴状细菌病和瘤瘤病
Mark J Taylor1, Achim Hoerauf, Moses Bockarie
1Liverpool School of Tropical Medicine, Liverpool, UK. mark.taylor@liv.ac.uk
Lancet (London, England)
|August 27, 2010
概括
淋巴状细菌病和淋巴状细菌病是热带寄生虫疾病,影响公众健康. 多西环素和其他药物,针对共生Wolbachia细菌,在治疗这些衰弱的虫感染方面表现有前途.
科学领域:
- 寄生虫学的寄生虫学
- 热带医学 热带医学
- 公共卫生 公共卫生
背景情况:
- 淋巴 filariasis 和 onchocerciasis 是主要的热带寄生虫疾病是由 filarial 线虫引起的.
- 这些感染导致慢性疾病,如淋巴,大象病,皮肤疾病和失明.
- 菲拉里亚线虫依赖于共生沃尔巴基亚细菌的生存和发病.
研究的目的:
- 审查淋巴性 filariasis 和 onchocerciasis 的病原和治疗.
- 突出沃尔巴基亚细菌在疾病中的作用和作为治疗点.
- 讨论当前的药物治疗和全球控制策略.
主要方法:
- 关于 filarial 疾病及其治疗的科学文献的综述.
- 对Wolbachia内共生体在线虫生物学和病变发生中的作用的分析.
- 目前药物治疗方法的概述,包括多克西环素,二甲基碳氨酸,艾弗梅克丁和阿尔本达.
主要成果:
- 沃尔巴基亚细菌对于 filarial 线虫的生存至关重要,并有助于炎症病理.
- 多西环林治疗向Wolbachia,显示出宏杀菌活性并改善了结果.
- 与二甲基碳氨酸,艾弗梅克丁和阿尔本达的组合疗法用于减少微细菌.
结论:
- 针对沃尔巴基亚的向疗法,特别是用多西环林,为治疗淋巴性 filariasis 和 onchocerciasis 提供了一种有前途的方法.
- 通过全球计划持续的药物供应对于中断传播和消除这些疾病至关重要.
- 综合治疗策略对于管理这些被忽视的热带疾病的公共卫生负担至关重要.
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