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Updated: May 10, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

一个小的病毒蛋白质对p53点基因的异染色素沉默

Conrado Soria1, Fanny E Estermann, Kristen C Espantman

  • 1Molecular and Cell Biology Laboratory, Salk Institute for Biological Studies, 10010 N. Torrey Pines Road, La Jolla, California 92037-1099, USA.

Nature
|August 27, 2010
PubMed
概括

腺病毒蛋白E4-ORF3通过表观遗传机制使瘤抑制剂p53 (也称为TP53) 沉默. 这种新的途径,独立于p53稳定,涉及形成一个核结构,阻止p53与DNA结合.

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