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IkappaBbeta在炎症反应期间抑制和激活基因表达

Ping Rao1, Mathew S Hayden, Meixiao Long

  • 1Department of Immunobiology and Department of Molecular Biophysics & Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

Nature
|August 27, 2010
PubMed
概括

卡帕Bβ抑制剂 (IkappaBβ) 在炎症中起着双重作用. 虽然它的降解促进了亲炎性基因表达,但它的核形式延长了瘤亡因子-α (TNF-α) 的产生,提供了治疗点.

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