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Updated: Jun 9, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones

Published on: February 7, 2019

不对称的温多洛辛,温多林和关键的温布拉斯类型的总合成

Yoshikazu Sasaki1, Daisuke Kato, Dale L Boger

  • 1Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.

Journal of the American Chemical Society
|September 3, 2010
PubMed
概括

使用一种新的循环添加级联,实现了vindoline和vindorosine的简洁合成. 这种方法有效地确定了关键的立体中心和结构特征,使得生物研究能够创建新的类似物.

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