在产期和产后分娩中出现脑
Dag Moster1, Allen J Wilcox, Stein Emil Vollset
1Department of Public Health and Primary Health Care, University of Bergen, PO Box 7804, N-5020 Bergen, Norway. Dag.Moster@smis.uib.no
JAMA
|September 3, 2010
概括
产生的时间影响脑 (CP) 风险. 怀孕40周出生是CP风险最低的,而早或晚分娩会增加婴儿的风险. 这凸显了最佳妊娠年龄对婴儿神经发育的重要性.
科学领域:
- 产科和妇科 产科和妇科
- 儿科神经学 儿科神经学
- 公共卫生流行病学 流行病学
背景情况:
- 过早分娩是脑 (CP) 的已知的危险因素,但大多数CP病例发生在满期婴儿中.
- 有限的数据存在于与妊娠年龄相关的CP风险在术期和术后期间.
研究的目的:
- 调查分娩时间 (产期和产后) 与患脑 (CP) 的风险之间的关联.
主要方法:
- 一项基于人口的随访研究利用了挪威的医学出生登记.
- 包括1,682,441个单独的婴儿出生在怀孕37周和44周之间 (1967-2001),不包括先天性异常.
- 在2005年之前通过国家登记处进行跟进,以评估至少活到4岁的儿童的CP风险.
主要成果:
- 在怀孕40周出生的婴儿CP患病率最低 (0.99/1000).
- 在37周 (RR 1.9) 和38周 (RR 1.3) 的分娩显示,与40周相比,CP风险增加.
- 在42周 (RR 1.4) 和之后 (RR 1.4) 的过期分娩也增加了CP风险.
- 当妊娠年龄通过超声波确定时,关联更为强烈.
结论:
- 在37,38,42周或更晚的孕期分娩与与40周分娩相比,脑 (CP) 的风险更高.
- 出生时的妊娠年龄是确定期内和期后婴儿CP风险的关键因素.
- 调查结果强调了优化交付时间的重要性,以减轻CP风险.
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