相关实验视频
Updated: Jun 9, 2026

11:44
Synthesis and Mass Spectrometry Analysis of Oligo-peptoids
Published on: February 21, 2018
奥利戈 ((4-aminopiperidine-4-carboxylic acid):一种不寻常的基本寡,具有由酸诱导的螺旋形状
Joon-il Cho1, Masahiro Tanaka, Sota Sato
1Department of Chemistry and Biotechnology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Journal of the American Chemical Society
|September 4, 2010
概括
基本的寡Api(8) 在酸性条件下形成螺旋结构. 它的螺旋形状在性pH值中由于皮佩里丁组相互作用而被破坏,影响了骨的键.
科学领域:
- 类化学 类化学
- 超分子化学 超分子化学
- 生物物理化学 生物物理化学
背景情况:
- 聚类中的螺旋形状通常通过键稳定.
- 带有充电侧链的基本多通常在各种pH水平上保持螺旋结构.
- 非天然的氨基酸4-aminopiperidine-4-carboxylic acid (Api) 具有独特的结构性质.
研究的目的:
- 研究基本寡Api的pH依赖的构造性行为 (8).
- 为了阐明4-aminopiperidine-4-carboxylic acid (Api) 残留物在Api(8) 结构中的作用.
- 了解Api中螺旋式诱导和干扰背后的分子机制 (8).
主要方法:
- 合成和表征的Api(8) 寡.
- 性定位以监测pH的构造变化.
- 核磁共振 (NMR) 光谱检测结构相互作用.
主要成果:
- Api(8) 仅在酸性介质中采用螺旋形状.
- 在pH值范围为7-10,观察到螺旋结构的破坏.
- 核磁共振研究表明,非质子化皮佩里丁基会干扰螺旋形成所需的键.
结论:
- Api的螺旋形状(8) 严重依赖于其Api残留物的质子化状态.
- 在非质子化Api残留物中的piperidine组相互作用会破坏螺旋结构的稳定.
- 皮佩里丁组的质子化或化可以诱导或稳定Api的螺旋结构 (8).
相关概念视频
Protein Organization
Overview
Protein Organization
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.
The primary structure of a protein is its amino acid sequence.
Amino acids
Amino acids are the monomers that comprise proteins. Each amino acid has the same fundamental structure, which consists of a central carbon atom, or the alpha (α) carbon, bonded to an amino group (NH2), a carboxyl group (COOH), and to a hydrogen atom. Every amino acid also has another atom or group of atoms bonded to the central atom known as the R group. There are 20 common amino acids present in proteins, each with a different R group. Variation in the amino acid sequence is responsible for...
Organic Compounds
All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
Basicity of Heterocyclic Aromatic Amines
Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
Carboxylic Acid Derivatives: Overview
Carboxylic acid derivatives are formed by replacing the hydroxyl group of carboxylic acids with a different functional group. The most common carboxylic acid derivatives are:

