殖民地形成单位与冠状动脉和腹腔大动脉化相关联
Susan Cheng1, Kenneth S Cohen, Stanley Y Shaw
1Cardiology Division, GRB-800, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA.
Circulation
|September 9, 2010
概括
对血管修复至关重要的内皮原生细胞数量较低,与动脉动脉样硬化增加有关. 这表明,降低血管新生潜力可能会推动疾病的发展.
科学领域:
- 心血管研究研究心血管研究
- 细胞生物学 细胞生物学
- 医学科学 医学科学 医学科学
背景情况:
- 内皮原生细胞 (EPC) 具有血管新生活性.
- 耗尽EPCs可能会促进动脉动脉生成.
- 有限的人类数据将EPC与亚临床动脉样硬化联系起来.
研究的目的:
- 研究EPC与人类亚临床动脉样硬化之间的关联.
- 确定EPC数是否与冠状动脉化和腹腔大动脉化相关.
主要方法:
- 研究了889名没有临床心血管疾病的弗雷明汉心脏研究参与者.
- 使用早期生长殖民地形成单元 (CFU) 试验和细胞表面标记物评估EPC.
- 通过使用计算机断层扫描进行冠状动脉化和腹腔大动脉化量化亚临床动脉样硬化.
主要成果:
- 下EPC殖民地形成单位与上冠状动脉和腹部大动脉化相关.
- 每次CFU的1-SD增加都与化减少约16-17%有关,独立于风险因素.
- 特定标志物 (CD34+/KDR+,CD34+) 与化没有显著的关联.
结论:
- 减少EPC数量与冠状动脉和大动脉中亚临床动脉样硬化负担增加有关.
- 降低血管生成潜力可能会导致人类群体的动脉样硬化发展.
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