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Updated: Jun 8, 2026

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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Published on: April 28, 2021

撤回:人类SIRT6通过CtIP脱乙化促进DNA末端切除

Abderrahmane Kaidi1, Brian T Weinert, Chunaram Choudhary

  • 1Gurdon Institute and Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK.

Science (New York, N.Y.)
|September 11, 2010
PubMed
概括

素6 (SIRT6) 蛋白质通过在双链断裂 (DSB) 修复过程中协助DNA末端切除,促进DNA修复. SIRT6对CtIP (C端结合蛋白相互作用蛋白) 的脱乙基化是这一过程的关键,增强了基因组的稳定性.

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