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端粒通过切断检查点信号传导路径来避免终端检测

Tiago Carneiro1, Lyne Khair, Clara C Reis

  • 1Instituto Gulbenkian de Ciência, Oeiras 2781-901, Portugal.

Nature
|September 11, 2010
PubMed
概括

端粒通过缺乏特定的表观遗传标记物 (如H4K20me2) 来阻止细胞循环停止,尽管它会招募DNA修复蛋白. 这种染色质特权确保了适当的染色体末端保护,而不会引发DNA损伤反应.

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