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Updated: Jun 8, 2026

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome
08:27

A Non-random Mouse Model for Pharmacological Reactivation of Mecp2 on the Inactive X Chromosome

Published on: May 22, 2019

从活跃的X染色体中阻碍Xist表达改善了小鼠体细胞核转移

Kimiko Inoue1, Takashi Kohda, Michihiko Sugimoto

  • 1BioResource Center, RIKEN, 305-0024 Tsukuba, Japan.

Science (New York, N.Y.)
|September 18, 2010
PubMed
概括

科学家通过识别和纠正特定的基因组重编程错误来改进哺乳动物克隆. 在克隆胚胎中删除Xist基因显著提高了克隆效率,并纠正了基因表达问题.

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