在具有多种心房动模式的人群中对心表膜激活的非侵入性表征
Phillip S Cuculich1, Yong Wang, Bruce D Lindsay
1Cardiac Bioelectricity Center, One Brookings Drive, St Louis, MO 63130-4899, USA.
Circulation
|September 22, 2010
概括
非侵入性心电成像 (ECGI) 允许对人类心房 (AF) 进行连续的双心房映射,揭示多种机制,并随着AF持续时间的增加而增加复杂性.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 电子生理学 电子生理学
背景情况:
- 心房动 (AF) 的机制在实验上得到了理解,但侵入性人体研究具有分辨率和连续性的限制.
- 持续,高分辨率地图的两个心房对于理解AF至关重要.
- 非侵入性心电成像 (ECGI) 为详细的AF绘图提供了一个潜在的解决方案.
研究的目的:
- 用ECGI在人类中呈现AF连续的双心上皮心激活序列.
- 评估ECGI用于映射AF机制的准确性和临床实用性.
- 分析AF复杂性,并非侵入性地识别常见的激活模式.
主要方法:
- 在接受节拍和切除的患者中,ECGI与CARTO成像和导管映射数据进行了验证.
- 在26名患者中分析了AF期间的ECGI地图,以确定机制和复杂性.
- 评估了ECGI的空间准确性,以确定步调启动地点.
主要成果:
- 在97%的患者中,ECGI成功成像了高空间精度的AF (6mm用于启动位置).
- ECGI确定了关键的AF维护部位,与成功的切除结果相关.
- 最常见的AF模式包括多个波段 (92%) 和焦点源 (肺和非肺静脉).
- 旋转器活动很少被观察到 (15%).
结论:
- ECGI提供了一种非侵入性,针对患者的方法,用于绘制AF表心活性图.
- AF机制是多样化的,患者特异的,复杂度不同.
- AF复杂性通常与条件的持续时间相关.
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