患有急性ST段升高心肌梗塞的患者的右室缺血损伤:用心血管磁共振进行表征
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Pier Giorgio Masci1, Marco Francone, Walter Desmet
1Department of Radiology, Medical Imaging Research Center, UZ Leuven, Herestraat 49, Leuven, Belgium.
Circulation
|September 22, 2010
概括
心肌梗塞后右心室 (RV) 缺血损伤很常见,通常是可逆的,并且可以通过心血管磁共振检测到. 早期的RV预示着功能改善,表明有限的永久性损伤.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 心肌梗塞研究研究
背景情况:
- 右心室 (RV) 显示出比左心室更大的缺血抵抗力.
- 由于在区分可逆性和不可逆性损伤方面存在挑战,对VR缺血性损伤的人类数据有限.
- 心血管磁共振 (CMR) 用于表征RV缺血性损伤在患有转发性心肌梗塞的患者.
研究的目的:
- 用CMR来表征RV缺血性损伤在患有转发性心肌梗塞的患者中.
- 评估RV损伤的存在,程度和可逆性.
- 为了确定RV损伤和RV功能之间的关系.
主要方法:
- 242名患有重流性急性ST段升高心肌梗塞的患者在1周和4个月后接受了CMR.
- T2加权和后对比CMR评估心肌胀和晚期加多增强 (LGE).
- 在基线和随访时评估RV功能.
主要成果:
- 在发心后早期的51%的患者中观察到RV,其中31%的患者显示LGE.
- 在33%和12%的前左心室心脏病发作中,分别存在RV和LGE.
- 在随访期间,RV独立预测RV全球功能改善 (β=0.221,P=0.003).
- 从早期到4个月的随访期间,RV LGE显著下降 (10%,P<0.001).
结论:
- 早期心脏病发作后的RV缺血性损伤,以和LGE为特征,是常见的.
- RV损伤发生在前部和下部心脏病发作中.
- CMR发现表明,急性RV功能障碍在4个月后可逆,有限的永久性损伤.
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