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肠道炎症提供了沙门氏菌的呼吸电子受体
Sebastian E Winter1, Parameth Thiennimitr, Maria G Winter
1Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, One Shields Avenue, Davis, California 95616, USA.
Nature
|September 25, 2010
概括
沙门氏菌Typhimurium利用炎症产生四酸盐,这是一种营养素,有助于它超越肠道中的其他微生物. 这种适应是病原体生存和传播的关键.
科学领域:
- 微生物学 微生物学
- 病原体与宿主相互作用
- 我们的肠道微生物组.
背景情况:
- 沙门氏菌 (Salmonella enterica) 血清型Typhimurium (S. Typhimurium) 诱导了急性肠道炎症. 这种炎症可以引起肠道炎症.
- 炎症增强了S. Typhimurium通过未知的机制传播,促进肠道光线的增长.
研究的目的:
- 阐明S. Typhimurium利用宿主炎症促进生长的机制.
- 确定S. Typhimurium在炎症肠道中使用的新型呼吸电子受体.
主要方法:
- 研究了炎症期间反应性氧物种和硫化合物之间的反应.
- 分析了四酸作为S. Typhimurium生长的呼吸电子受体的作用.
- 评估了四甲酸盐在炎症肠道光线中呼吸所带来的竞争优势.
主要成果:
- 在炎症过程中产生的反应性氧物种与硫酸硫酸盐反应,形成四酸盐.
- 三酸盐作为一种新型的呼吸电子受体,用于S. Typhimurium.
- 能够利用四酸盐的基因为S. Typhimurium提供了相对于竞争中的微生物群的显著增长优势.
结论:
- S. Typhimurium 毒性因子会触发宿主产生三酸盐,这是一个独特的电子受体.
- 这种由宿主驱动的适应使得S. Typhimurium能够利用呼吸来与发酵的肠道微生物竞争.
- 诱导肠道炎症的能力对于S. Typhimurium作为腹病原体的生物成功至关重要.
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