阿尔基因同同二氧化与马洛诺过氧化物
James C Griffith1, Kevin M Jones, Sylvain Picon
1School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff CF10 3AT, UK.
环甲氧化物 (1) 提供一种有效的二氧化方法,产生高效率 (40-93%) 的二醇. 这种反应对1,2-非替代基具有显著的合成选择性.
科学领域:
- 有机化学 有机化学
- 合成化学 合成化学
背景情况:
- 基二化是有机合成中的一个基本转化.
- 开发高效和选择性的二化方法仍然是研究的一个活跃领域.
研究的目的:
- 引入环烯醇过氧化物 (1) 作为二氧化的新型试剂.
- 调查二基化反应的立体选择性,特别是与1,2-异位基.
主要方法:
- 从商业上可获得的二氧化酸中制备的环烯甲氧化物 (1).
- 基与试剂1在40°C的水中发生反应.
- 介质的性水解产生最终的二醇产品.
主要成果:
- 环 propyl malonoyl 过氧化物 (1) 有效地二化基,提供二醇在40-93%的产量.
- 该反应对1,2-非替代具有很高的合成选择性,选择性比率从3:1到50:1以上.
- 氧气标记研究支持拟议的反应机制.
结论:
- 环 propyl malonoyl 过氧化物 (1) 是一种有价值和高效的试剂,用于二氧化.
- 该方法提供了对合成二醇的立体选择性途径,扩大了合成的可能性.
- 拟议的机制为反应途径提供了洞察力.
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