将癌症研究转化为有针对性的治疗方法
1The Institute of Cancer Research, Cotswold Road, Sutton, Surrey SM2 5NG, UK. johann.de-bono@icr.ac.uk
Nature
|October 1, 2010
概括
癌症药物开发正在向向治疗转移,但仍然缓慢. 未来的进展依赖于针对个性化医学的综合研究和生物标志物驱动的临床试验.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 生物技术是生物技术.
背景情况:
- 传统的化疗正在被向性癌症药物所取代.
- 尽管取得了进展,但癌症药物开发是一个漫长且低效的过程.
研究的目的:
- 确定当前癌症药物开发中的挑战.
- 提出改善和加速药物开发管道的战略.
主要方法:
- 审查癌症药物开发的当前趋势.
- 分析阻碍该过程的问题.
- 关于综合研究和适应性临床试验设计的建议.
主要成果:
- 转向分子向药物的转变显示出对疗效和减少副作用的承诺.
- 在为患者提供新的癌症药物方面,仍然存在严重的延迟.
结论:
- 综合癌症研究和生物标志物驱动的适应性试验至关重要.
- 个性化癌症医学需要对患者和瘤遗传学和生物学有深入的了解.
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