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Updated: Jun 8, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
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通过循环和交叉链接的寡核酸识别非常高亲和度的DNA

Narayan C Chaudhuri1, Eric T Kool

  • 1Contribution from the Department of Chemistry, University of Rochester, Rochester, New York 14627.

Journal of the American Chemical Society
|October 1, 2010
PubMed
概括

研究人员开发了一种新的DNA修饰,用于在非互补的DNA链之间创建共价交叉链. 这种策略增强了DNA结合亲和力和序列选择性,为DNA识别提供了一种新的方法.

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